| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Characterization and Function of the First Antibiotic Isolated from a Vent Organism: The Extremophile Metazoan Alvinella pompejana
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| Autores: |
Tasiemski, Aurelie
Jung, Sascha
Boidin-wichlacz, Celine
Jollivet, Didier
Cuvillier-hot, Virginie
Pradillon, Florence
Vetriani, Costantino
Hecht, Oliver
Soennichsen, Frank D.
Gelhaus, Christoph
Hung, Chien-wen
Tholey, Andreas
Leippe, Matthias
Groetzinger, Joachim
Gaill, Francoise
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| Data: |
2014-04
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| Ano: |
2014
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| Resumo: |
The emblematic hydrothermal worm Alvinella pompejana is one of the most thermo tolerant animal known on Earth. It relies on a symbiotic association offering a unique opportunity to discover biochemical adaptations that allow animals to thrive in such a hostile habitat. Here, by studying the Pompeii worm, we report on the discovery of the first antibiotic peptide from a deep-sea organism, namely alvinellacin. After purification and peptide sequencing, both the gene and the peptide tertiary structures were elucidated. As epibionts are not cultivated so far and because of lethal decompression effects upon Alvinella sampling, we developed shipboard biological assays to demonstrate that in addition to act in the first line of defense against microbial invasion, alvinellacin shapes and controls the worm's epibiotic microflora. Our results provide insights into the nature of an abyssal antimicrobial peptide (AMP) and into the manner in which an extremophile eukaryote uses it to interact with the particular microbial community of the hydrothermal vent ecosystem. Unlike earlier studies done on hydrothermal vents that all focused on the microbial side of the symbiosis, our work gives a view of this interaction from the host side.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
http://archimer.ifremer.fr/doc/00219/33052/31517.pdf
DOI:10.1371/journal.pone.0095737
http://archimer.ifremer.fr/doc/00219/33052/
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| Editor: |
Public Library Science
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| Formato: |
application/pdf
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| Fonte: |
Plos One (1932-6203) (Public Library Science), 2014-04 , Vol. 9 , N. 4 , P. 1-10
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| Direitos: |
2014 Tasiemski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
info:eu-repo/semantics/openAccess
restricted use
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